No abstract

The first drug discovered to be involved in the development of gingival hyperplasia is phenytoin, which is indicated in the treatment of epileptic patients. The other drugs are calcium channel blockers with vasodilating effect. The most important one is Nifedipine, while Ciclosporin A, which is used as an immunosuppressant in the prevention of transplant rejection, causes gingival hyperplasia as a secondary effect. Gingival hyperplasia can reach an impressive volume, completely covering the dental crown and affecting the masticatory and physiognomic functions. The elucidation of the mechanism, by which drug-induced gingival hyperplasia occurs, favoring factors and the choice of conservative or surgical treatment methods, emphasizing the prophylactic treatment. The study batch was subject to intraoral and extraoral clinical examinations and the data were included in the dental treatment sheet of each patient, 11 patients aged over 60 years, who came to the Clinic ... in the period 2014-2016. The diagnosis was based on the anamnesis, the clinical aspect of the lesions and the histopathological examination. After the surgical excision of the hyperplasia affected area, recurrence was prevented by dispensarizing the patients and controlling the bacterial plaque through rigorous oral hygiene. Treatment depends on the severity of the lesions, as well as on the physionomic and masticatory functions. Conservative etiological therapy is attempted, by removing the bacterial plaque and local irritant factors, by reducing the dose of drugs, or by changing the systemic medication.

The Pasteur principles regarding the cause of infection and the measures that need to be taken in order to prevent it have become a necessity of the first rank, representing, at the same time, the decisive factor of progress in modern dentistry. Nowadays, based on these principles, from the simplest bandage to the most complex surgery, these are carried out with the help of materials, dental hands and a surgery area where the pathogenic germs have been destroyed. These measures are based on asepsis and antisepsis, methods that perform the disinfection. Asepsis represents the prophylactic side of the disinfection and addresses all the moments that present the risk of contamination. It represents the set of measures by means of which the contact between germs and surgery or accidental plague is avoided. It is a prophylactic method. Antisepsis represents the totality of the means by which the destruction of the germs present in a plague, on the skin or in the environment is sought; it is a curative method. The main mechanisms of action of antiseptics on microorganisms are: altered outer membrane, amino group blockage, tiolitic group blockage, inhibition of ergosterol synthesis, cytoplasmic membrane alteration, energy decoupling, intracytoplasmic clotting. The study comprises 135 sterilizations performed over a period of two years; 107 (79.26%) were done in autoclaves, 7 (5.18%) in ethylene oxide, and 21 (15.56%) in hydrogen peroxide. The use of an antiseptic for long periods of time must be avoided due to the fact that, in the case of those containing heavy metals in their structure, they can be cumulated in the human body, and when toxic concentrations are reached, various toxicities can be triggered.

Thrombophilia, also called hypercoagulability or prothrombotic condition, usually reflects a certain imbalance that occurs either in the coagulation cascade or in the anticoagulation/fibrinolytic system. A similar imbalance may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thrombotic complications are associated with multiorgan failure and increased mortality. In this context, activation of coagulation and thrombocytopenia appeared as prognostic markers in COVID-19. Our work provides a structured and updated analysis of inherited thrombophilia and its involvement in COVID-19, emphasizing the importance of diagnosing and initiating thromboprophylaxis. Since the state of hypercoagulation is directly correlated with COVID-19, we consider that studies on the genetic profiles of proteins involved in thrombophilia in patients who have had COVID-19 and thrombotic events are of great importance, both in treating and in preventing deaths due to COVID-19.

There is no doubt that many psycho-emotional factors interfere with and produce changes in reproduction. Neglecting them means depriving our actions of efficiency because they will be incomplete. The adoption of the general term malformation syndrome to encompass all malformations draws attention on policy conditions set and communicate any teratologic process. Being a metabolic disease with clinical manifestations and multiple biochemical alterations, diabetes is a frightening scar of our century, considered to be the most important disease, which in itself leads to buccal-maxillo-facial polymorphic alterations. The study group consisted of 90 patients with congenital diabetes and stomatologic problems, aged between 26 and 65 years, the average age being 45 years. Distribution by gender: 60 men and30 women. Periodontal lesions are disturbing or distressing inflammation hyperplasic tissues of periodontium and quantity independence tissue affected to delineate both gingivitis and periodontitis. The most important factor in the epidemiology of the periodontal disease for prophylaxis is oral hygiene.