Many pathogens can co-infect humans and animals. The present study aims to analyze the frequency of reported cases of zoonoses in humans and confirmed cases of canine distemper in the municipality of Presidente Figueiredo through the extraction of information from the Information System of Notifiable Diseases of the Ministry of Health (SINAN) and the epidemiological investigation reports of outbreaks produced by the health surveillance room of the Zoonosis Control Center of the Municipality of Presidente Figueiredo-AM in the period 2017-2020. In the state of Amazonas, in the analyzed period, there were reported cases of Rabies, Visceral Leishmaniasis, Tegumentary Leishmaniasis, Leptospirosis, Spotted Fever, Hantavirus, and Acute Chagas Disease. In the municipality of Presidente Figueiredo, only the zoonoses of Tegumentary Leishmaniasis and Leptospirosis were reported, and an outbreak of distemper occurred in 2020, which affected 17 animals and exposed another 10 animals susceptible to infection. During the outbreak of disease with neurological signs in dogs in the municipality, the epidemiological surveillance technicians promoted an epidemiological investigation, clinical and laboratory analysis of the affected animals and concluded based on the data and results that it was an outbreak of Distemper. Therefore, there is an occurrence of the distemper virus in dogs in the municipality of Presidente Figueiredo, and although neurological cases in dogs have not been detected as resulting from infection by the rabies virus, the constant surveillance and investigation work is highlighted as essential to ensure the one health in the municipality, in view of the differential diagnosis of rabies.