Background: Digitisation affects our working environment. It demands new cognitive and digital skills of healthcare employees. Technostress and burnout are more likely to occur due to the additional workload. Aim: Objective is the identification of determinants affecting work related technostress. Methodology: We carried out a systematic review according to the PRISMA statement. For the identification of the digital factors, we applied an inductive content analysis based on Mayring’s theory. Results: Included studies showed the following factors to be relevant for coping with technostress: autonomy, competence, understanding of roles, time pressure, attitude, security and ergonomics. The emerging factors serve the regulation of stress in the healthcare system and contribute to better healthcare and higher occupational safety.