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Background/Aims: Pressure-overload (PO) causes cardiac hypertrophy (CH), and eventually leads to heart failure (HF). HF ventricular myocytes present transverse-tubules (TT) loss or disarrangement and decreased sarcoplasmic reticulum (SR) density, and both contribute to altered Ca²⁺ signaling and heart dysfunction. It has been shown that TT remodeling precedes HF, however, it is unknown whether SR structural and functional remodeling also starts early in CH. Methods: Using confocal microscopy, we assessed TT (with Di-8-ANNEPS) and SR (with SR-trapped Mag-Fluo-4) densities, as well as SR fluorophore diffusion (fluorescence recovery after photobleach; FRAP), cytosolic Ca²⁺ signaling and ex vivo cardiac performance in a PO rat hypertrophy model induced by abdominal aortic constriction (at 6 weeks). Results: Rats developed CH, while cardiac performance, basal and upon β-adrenergic stimulation, remained unaltered. TT density decreased by ∼14%, without spatial disarrangement, while SR density decreased by ∼7%. More important, FRAP was ∼30% slower, but with similar maximum recovery, suggesting decreased SR interconnectivity. Systolic and diastolic Ca²⁺ signaling and SR Ca²⁺ content were unaltered. Conclusion: SR remodeling is an early CH event, similar to TT remodeling, appearing during compensated hypertrophy. Nevertheless, myocytes can withstand those moderate structural changes in SR and TT, preserving normal Ca²⁺ signaling and contractility.

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Introducción: La terapia de sustitución renal con diálisis peritoneal es una modalidad segura para la enfermedad renal crónica terminal. Los resultados son comparables con pacientes en hemodiálisis por lo que lo hace una modalidad costo efectiva, especialmente en países en vía de desarrollo. Algunas complicaciones que se pueden presentar debido a diálisis peritoneal son: peritonitis, fuga, hernias, falla de filtración y disfunción del catéter. Una de las complicaciones infrecuentes de la diálisis peritoneal es la formación de un pseudoquiste peritoneal. Caso Clínico: Presentamos un caso de un paciente en terapia de sustitución renal con diálisis peritoneal, el cual presenta un pseudoquiste peritoneal como complicación de diálisis peritoneal.  complicaciones; dialisis peritoneal; pseudoquiste peritoneal

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