Objective: The aim of this study was to invastigate the validity and reliability of the Turkish version of the Professional Quality of Life Scale (ProQOL R-IV). Methods: One hundred health professionals participated in the study. All participants were assessed using the ProQOL R-IV, the Burnout Inventory and the Brief Symptom Inventory the Turkish versions. Results: A moderate correlation was observed between the Turkish Version of the ProQOL R-IV (and its subscales) and the Brief Symptom Inventory (and its subscales). The ProQOL R-IV was correlated with Burnout Inventory and Brief Symptom Inventory (respectively, r=0.391, p<.01, r=0.401, p<.01). The Cronbach's alpha value of the scale was 0.848. Conclusion: This study demonstrated that the Turkish version of the ProQOL R-IV is a valid and reliable instrument. It is assumed that the scale might be especially useful in the assessment of professionals in stressful working conditions and may provide the clinician with data contributory for the management of these subjects. (Archives of Neuropsychiatry 2010; 47: 111-7)