SUMMARY We studied the effects of cholinergic receptor activation on cerebral blood flow in dogs anesthetized with chloralose. Continuous measurements of cerebral blood flow, arterial and cerebral spinal fluid pressure, heart rate, and respiratory carbon dioxide tension were made during parasympathetic nerve stimulation and during intraarterial infusion of acetylcholine. Multiple samples of arterial and cerebral venous blood were taken before, during, and after cholinergic vasodilation and analyzed for oxygen tension, carbon dioxide tension, and pH. Dose

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