Background: Oxidative stress increases vascular permeability though caveolin-1 phosphorylation. The exact role of AMPK is unknown. Results: AMP-dependent kinase (AMPK) inhibits caveolin-1 phosphorylation by stabilizing the interaction between c-Abl and Prdx-1.
Conclusion: AMPK activation inhibits oxidant induced-vascular permeability.Significance: The present study shows a novel protective role of AMPK in the vascular homeostasis.
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