INTRODUCTION. THE present work was undertaken to extend the recent investigations of Harris, Gaffron, and others on the photo-dynamic oxidation of certain organic substances and to establish new data on the dynamics of this type of reaction. It was hoped that the information thus obtained might provide a basis for the explanation of the skin lesions and other manifestations exhibited by individuals sensitised to light by the occurrence in their tissues of certain fluorescent porphyrins. Fischer [1924], Garrod [1922] and Gray [1924] have reported in detail cases of haematoporphyrinuria congenita in which uroand copro-porphyrin can be identified in the organs and excreta. Hausmann [1926] has described the symptoms produced in man and in small animals by injections of small doses of haematoporphyrin on exposure to light. Raab [1903], Tappeiner and Jodlbauer [1905], Dreyer [1904], Ledous Lebard [1902] and others have produced analogous effects on protozoa, bacteria, enzymes, toxins and immune bodies by the action of various fluorescent synthetic dyes in the presence of light. Harris [1926] has shown that proteins such as egg

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