Plumbum (Pb) is one of heavy metals that can turn into free radicals, resulting in the descent and alteration of cell structures of the stomach. Apple of Rome beauty contains high flavonoids which act as antioxidant agents by supplying hydrogen ions to the free radicals. This research utilized white rat (Rattus norvegicus) divided into 5 treatment groups, each group consisted of 4 white rats. They are negative control, positive control which were given 10 mg of Pb acetate for each rat/day in 14 days, and preventive control group which were given the extract of Rome Beauty apple peel within the dosage of 28 mg/200 g, 56 mg/200 g, and 112 mg/200 g for 21 days. The parameter observed were MDA levels of stomach. The result was then analysed with One Way ANOVA which was followed by Turkey. The result of this research exhibited the preventive group which was given Rome Beauty apple peel within the dosage of 112 mg/200 g was able to halt the increase of MDA levels significantly (p<0.05), which was 82.16 ± 1.40 μg/ml. The research concluded that Rome Beauty apple peel contain antioxidant that can prevent the damage of stomach tissue resulted by Pb acetate.