При изучении морфологии стенки сосудов у 18 умерших в возрасте от 45 до 55 лет с признаками хронической болезни почек (ХБП)-выявлены изменения характерные для иммунного воспаления, что сопровождается низкой экспрессией VEGF и bcl-2, что создает предпосылки к активации апоптоза и может быть основной причиной сердечно-сосудистых осложнений Ключевые слова: морфология, аорта, коронарные артерии, хроническая болезнь почек, VEGF, bcl-2 The most important functions of endothelium are: hemostasis regulation, inflammation modulation, vascular tone correction, vascular permeability regulation. Chronic pulmonary disease (CPD) breaks this balance and predisposes vessels to vasoconstriction, leukocyte adhesion, platelet activation, mitogenesis, inflammation. The aim of the work was to study morphological changes of the cardiovascular walls and aorta in patients with CPD and to assess the possibilities of its endothelium to reparation. Materials and methods. There was studied an autopsy material of 18 died persons 45-55 years old. All died persons had the signs of chronic pulmonary disease (CPD). For detection of the immune cellular reaction features in zone of inflammation process there were used the primary homogenous antibodies (HGAB) of DAKO (Denmark), Rady-to-Use. The studies were carried out on microscope Primo Star (Carl Zeiss) using AxioCam (ERc 5s). Results and discussion. The changes of endothelium of coronary vessels of heart and aorta were demonstrated with the different degree of disorganization. These pathologic processes were familiar to the immune inflammation. The weak expression of the growth factor of VEGF and bcl-2 vessels endothelium can be the indirect sign of the low ability of the vascular wool structure and endothelium lining to reconstruction because an activation of apoptosis takes place at its deficiency. Conclusions. The changes of coronary arteries and aorta construction at CPD are characterized with unidirectional nature with the different intensity of pathologic process in all layers of the vascular wall and vascular transformation that is typical for immune inflammation. The detected disorders of vascular morphology and immunoinflammatory reaction activity can be the one of the main causes of cardiovascular complications development

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Introduction: Vascular endothelium function interruption has the main role among mechanisms of development and progression of chronic kidney disease. In numerous experimental and clinical studies, it was proved that activated vascular endothelium is a structural and functional unit that matches processes of inflammation with intravascular coagulation, fibrinolysis and haemorheological disorders. The aim: To identify special features of endothelium morphological structure in kidney vessels, coronary arteries and aorta during chronic kidney disease. Materials and methods: Based on autopsy materials, we conducted a morphological study of patients (n = 20) aged 45 to 55 years who were observed in cardiac and neurological hospitals for 5-7 years. We removed kidney, heart and aorta samples from patients. For the study, a histological and immunohistochemical methods were used. Results and conclusions: Morphological study of vessels endothelium of kidneys, heart and aorta demonstrated that in the majority of observations intima underwent profound pathological changes, manifested by different degrees of disorganization of endothelial lining and violations of structural and functional organization of the endotheliocytes, subendothelial layer, basal membrane. These pathological processes in all cases had similar features with the development of immune inflammation. Inflammatory infiltration was represented by macrophages, mast cells, plasma cells. Biological mediators of the presented cells can aggravate the damage to endothelial cells. Indirect signs of low ability to restore the structure of the vessel wall and endothelial lining may be a weak expression of the VEGF and bcl-2 vascular endothelial growth factor.

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