Tissue MR imaging is a feasible method to assess Ea. Combining E and Ea allowed similar estimation of filling pressure by MR and Doppler, in good agreement with invasive measurement. The potential confounding effect of valvular regurgitation needs further study.
Figure 5. (A) Correlation between magnetic resonance (MR)-measured E/A and invasive mean pulmonary capillary wedge pressure (PCWP). Note absence of correlation (p ϭ 0.99). (B) Correlation between posteroseptal MR-measured E/Ea and invasive PCWP (R 2 ϭ 0.65, p Ͻ 0.0001). (C) Bland-Altman plot of the difference between MR-estimated and cathetermeasured PCWP. Horizontal lines show the mean difference between two methods Ϯ 2 SDs. A ϭ peak mitral velocity at atrial contraction; E ϭ peak mitral velocity in early diastole; Ea ϭ early diastolic tissue velocity.
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