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Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.

Deepwater wells in the 'Lower Tertiary' play in the Gulf of Mexico are completed through large vertical intervals comprising of multiple high pressure hydrocarbon layers with low permeability. Operators are faced with numerous challenges to economically produce these reservoirs including: low permeabilities requiring multiple hydraulic fractures; highly pressured, deeply buried reservoirs over large intervals to complete and isolate; and high differential pressures during stimulation and production. The technology currently in use tends to address many of these challenges, however the productivity of these wells is still relatively low and the well costs remain high. This paper will review the challenges encountered in these wells, and the technologies currently used to address them. It will also outline potential well design and construction approaches for consideration by industry to improve well productivity and increase reliability. 2OTC-26988-MS