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Territories with arid climate are characterized by insufficient atmospheric humidification at high air temperatures. Therefore, the use of drip irrigation during the growing season of plants is an effective agrotechnical method of farming. However, its use causes a number of unfavorable consequences that can be avoided by using biological plant protection agents with pronounced biological activity against phytopathogenic bacteria, micromycetes, insects and viruses. These remedies are based on the introduction of microorganisms and their metabolites into the biotechnological process. A biological plant protection agent based on Bаcillus atrophaeus ACIM В–11474 has been developed and its effect on the mycocenosis of the studied soils when growing lettuce in the arid climate of the Astrakhan region using drip irrigation has been studied.