In recent years, the cluster approach has become one of the main methods used in public administration both in Russia and abroad. Economic security is the basis of strategic planning designed to implement the strategic national priorities of the Russian Federation, and plays a dominant role in the economic stability of the country. Therefore, it is important to evaluate the economic security of the constituent entities of the Russian Federation. The article identifies indicators that affect the economic security of the constituent entities of the Russian Federation. Based on the indicators listed in the economic security strategy of the Russian Federation for the period until 2030, the distribution of regions by cluster is presented. The study period is 8 years from 2010 to 2017. The analysis is carried out on the subjects of the Russian Federation based on 24 indicators.