No abstract

The fact that many patients all over the world use homeopathic ultra high diluted succussed medicinal products, makes very interesting an explanation about the structure of them since until now only unconfirmed hypotheses are made. The present study focuses on the still unanswered questions about what happens with the chemical composition and the physicochemical properties of these products using Hypericum Perforatum L as a representative paradigm. All samples were prepared according to manufacturing procedures described mainly in S. Hahnemann's "Organon" and were examined by SEM, XRD, FTIR, DLS micro Mastersizer, DLS nano Zetasizer, UV-Vis and TEM. Measurements of electrical conductivity and pH were effectuated by the appropriate devices. During trituration of source material in alpha-lactose monohydrate some functional chemical groups present in source material disappeared and some others new ones came in view at the end of the process. A differentiation upon physicochemical properties between the source material and final triturating product was viewed, as well as micro-nanoparticles in colloidal form in all potencies derived trituration or extraction origin were present. The findings showed that the whole preparation process leads to the creation of micro nanoparticles something that for solid origin these products are created by trituration and for extract origin products these nanoparticles exist from the beginning.

For many years now, homeopathy is considered to be an alternative and more physical way of treatment compared to traditional medicine. Though, little has yet been scientifically studied upon the matter. The scope of this paper is to investigate the relationship between the size-shape variations of eight starting Raw Solid Materials (RSM) and the role of trituration in the size-shape of these RSM's before they are turned into solutions. These materials are used in homeopathy as remedies, after successive grindings, before they are turned into homeopathic solutions. What is more, their fracture surface fractal dimension is investigated. The trituration process will be analyzed, which in homeopathic pharmacology leads to the substances having self-affined fractal structure regardless their type or hardness (metals, minerals, salts, shells, dry plants, etc.), a structure only depending on the size and shape of the powder grains of the starting RSM. The physical meaning of these results is that at the end of the process there is a gradual transformation of the size and shape of the original RSM during the trituration, depending on the physical condition of the materials before grinding them. In this paper, it is proved that, regardless of the starting RSM, the fixed trituration formalism used in Homeopathic Pharmacopoeia leads to a result which depends only on the powder grains size of the starting RSM.