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This study aimed to evaluate Butaro Hospital's supply chain management practices and quality performance. Study's goals were to evaluate the impact of procurement of health commodities processes on quality performance, to assess the effects of storage and distribution of health commodities processes on quality performance and to determine the role of electronic logistics management information system (e-LMIS) on quality performance of Butaro Hospital. A descriptive research design carried out, utilizing both qualitative and quantitative data, study's design directed the data collection, analysis, and interpretation processes. Sample size of the study made up with 62 respondents were selected by using a census sampling method from the five different departments which are concerned with hospital supply chain management practices and quality performance of Butaro Hospital. Collected data were analyzed by SPSS version 22.0 for descriptive analysis and inferential statistics analysis, thematic analysis was applied to data captured from interviews. Findings shows that procurement of health commodities and quality performance are positively correlated, as shown by a positive coefficient; this relationship is statistically significant (p=0.0220.05). One-unit increase in the procurement of health commodities will result in a quality performance score of (0.119). Probability is (p=0.440.05), which indicated that there is a positive correlation between distribution and storage of health commodities on quality performance. (e-LMIS) has a statistically significant positive correlation on quality performance, with a probability of (p=0.0000.05) and a contribution to quality performance of (0.807). Quality performance of Butaro Hospital changes by 0.109 due to an increase of one unit. Study concluded that supply chain management practices have a positive impact on quality performance of Butaro hospital, by ensuring the availability of medicines at the dispensing points, ensuring the effective services delivery and promotes Hospital’s performance in general. It recommended that Butaro Hospital should improve internet connectivity availability in order to provide better services delivery and to be able to navigate and efficiently use (e-LMIS) system in health supply chain cycle. And that the Hospital should invest in the storage facilities and have a required enough storage space together with required materials and equipment to promote a good storage practice (GSP). Keywords: Supply chain management, Quality performance, Butaro Level II Teaching Hospital, Healthcare logistics, Inventory management.