Acne, also known as acne vulgaris (AV), is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. The investigation is expected to evaluate serum level of betartophien protein in patients with skin break out vulgaris and contrast it with its level in solid control. This is A case -control study, was led on 80 patients isolated into 2 groups:(Group A); 60 patients experiencing skin break out vulgaris, (Group B); 20 obviously sound people of coordinated age and sex. All examined subjects were tried forSerum level of Betatrophin. Higher betatrophien level was altogether connected with higher seriousness higher betatrophien level was fundamentally connected with male sexual orientation, PCOD, hairsuitism, androgenetic alopecia. The betatrophien level in AV bunch was essentially higher when contrasted with control gathering . Betatrophien level was proposed to be autonomous indicator of AV defenselessness and seriousness.

Alopecia areata is a common cause of non-scarring alopecia that occurs in a patchy, confluent or diffuse pattern. The EGF can promote growth of the ORS compartment of mink hair follicles in vitro, and enhance proliferation and migration of the ORS cells via activation of the Wnt/β-catenin signaling pathway.Evaluation of serum levels of EGF in patients with alopecia areata.Serum EGF concentrations were measured in 60 consecutive patients with alopecia areata in comparison with 25 controls using enzyme-linked immunosorbent assay (ELISA).Serum levels of EGF were found to be higher in patients than in healthy controls.increased serum levels of EGF in patients than in controls probably reflect the role of EGF in the pathogenesis of alopecia areata.