The pathogenesis of chronic rhinosinusitis with nasal polyposis is still unknown. The aim. To estimate IgE-antibodies to staphylococcal enterotoxines and fungal allergens mix in nasal polyps'supernatant and sera of three phenotypes of chronic rhinosinusitis. Patients and methods. Chronic rhinosinusitis with nasal polyposis with aspirin intolerance - 12 patients, chronic rhinosinusitis with nasal polyposis with atopy - 15 patients, chronic rhinosinusitis with nasal polyposis without atopy and aspirin intolerance - 10 patients, and 6 healthy persons were observed. The levels of ECP, tryptase, total IgE, IgE-antibodies to staphylococcal enterotoxines, fungal mix in sera and supernatant of polyp's tissue were detected by ImmunoCaplOO (Phadia AB). Results. The incidence of IgE-antibodies to staphylococcal enterotoxines makes up 12,6% in the sera of all patients, and 30% in polyp's tissue in nonatopic patients and in none of atopics. The local production of IgE-antibodies to fungi in polyp's tissue was high and revealed in 30-73% of all patients (more often in patients with aspirin intolerance - in 73% of cases). There was no dependence between the incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in the sera and polyps and the chronic rhinosinusitis with nasal polyposis. Conclusion. The incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in polyp's tissue is higher than in sera as in atopic as in nonatopic pts. There were IgE-antibodies to fungi in polyp's tissue in 73% of patients with aspirin intolerance. The presence of IgE-antibodies did not influence on the level of ECP and severity of chronic rhinosinusitis with nasal polyposis .