Very recently, ToMITA and coworkers' 2) have reported the fermentation, isolation and structure elucidation of gilvocarcins V (1) and M (2). They note that I was previously described under the name of toromycin by HORII et al.3) although the structure of toromycin was not elucidated. Recently we have isolated 1 and 2 and a related compound gilvocarcin E (3) from a culture of Streptomyces anandii subsp. araffinosns strain C-22437 (ATCC-31431).* The producing culture was isolated at BristolLaboratories from a soil collected in Katpadi, Madras, India. We report here the isolation, structure elucidation and biological activities of compounds 1. 3.
Isolation of Gilvocarcins V, M and E
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