Drug provocation tests in individuals with suspected drug allergy performed in carefully controlled settings can confirm drug hypersensitivity.

Thus, in most cases, the in vitro Cys-LT test has little or no diagnostic utility and is not superior to histamine release.

The usefulness of the in vitro histamine-release test for the diagnosis of drug allergy appears to be insufficient.

The clinical history of paracetamol (acetaminophen) hypersensitivity is rarely sufficient to set a firm diagnosis and only OPT can confirm this. Careful OPT reproduces the same symptoms (not more severe in our hands) with the same or slightly more delayed chronology. Atopy and sex are not risk factors.