Ayurveda an ancient healing system, is a system of understanding human health that has been termed as the "Mother of All Healings. It helps preventing disease, diagnosis, and treatment through the use of a unique, personal method that is based on an evaluation of each patient's constitution. Researchers from all over the world isolated various photochemicals from herbs and recreated their effects with compound pharmaceuticals. In this reviwew we focused about phytopharmacology of Hemidesmus indicus such as analgesic, antiinflammatory, antipyretic, antiarthritic, antioxidant, antiacne, antipsychotic, anti-diarrhoeal, wound healing, antiulcer, larvicidal, antivenom, antihyperlipaedaemic, antimicrobial, anti-carcinogenic activities.