Methods of embryo selection are based on invasive or noninvasive procedures which have a significant individual benefits and limitation that affect to transfer healthy embryo into uterus. Invasive techniques of preimplantation genetic diagnosis (such as FISH, CGH, PCR) increase implantation rates and reduce frequency of anomalies that are typical for developmental embryos. Using and improvment these techniques represent an effective strategy to reduce multiple gestation because of possibility to transfer singelton embryo during one IVF cycle. Non-invasive techniques such time-lapse microscopy represent new methodology that occur to analyse embryo in stable culture conditions without a risk of sample contamination or sample error. The aim idea of this review was to mention on variable techniques of selecting embryo, their positive and negative statement, and bring a future direction to eventual research.