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This incomplete list of the advantages which toxoid possesses may be supplemented by the statement that results obtained in the vaccination of a group of young adults revealed the fact that the immunizing qualities of this prophylactic were as readily demonstrable in human beings as in experimental animals.Upon the completion of this preliminary work, arrangements were made in a number of centers for more extended use of diphtheria toxoid prepared in the Connaught Laboratories. These further trials, notably in Hamilton, Windsor, and Brantford, Ontario, were eminently successful. Very quickly the use of toxoid spread to other parts of Canada and soon its employment upon a large scale was undertaken. This very satisfactory state of affairs has continued, and in the past 6 years sufficient toxoid for the vaccination of over 1,000,000 persons has been distributed in the Dominion.

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Summary Injection of ducks with diphtheria toxoid resulted in the appearance of antitoxin in their blood serum. The amount of antitoxin present showed wide individual variations. The immunity was found to protect against injections of diphtheria toxin. The serum antitoxin decreased rapidly after injections were discontinued. The decrease coincided with the time when the birds began to lay eggs. The eggs were found to contain antitoxin in the livetin fraction of the egg yolk. The concentration of antitoxin in the yolk was found to vary with the concentration in the serum. The amounts of the proteins vitellin and livetin in unit volume of egg yolk were found to vary independently of each other, and independently of the individual which laid the eggs. No relation was found between yolk livetin concentration and yolk antitoxin concentration. Ducklings newly hatched from eggs laid by immunized birds were found to contain antitoxin in their blood serum. None could be found in the serum of three weeks' old ducklings from the same mothers.

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