To see if results in rats, rabbits, and dogs at high dose levels justified extrapolation, the fate of butylated hydroxyanisole in man was studied. Further possible pathways were sought in dogs. Dogs excreted 60% of a 350 mg. per kg. dose unchanged in the feces within 3 days, and the remainder in the urine largely as sulfate conjugates of BHA, ferf-butylhydroquinone, and an unidentified phenol. Little glucuronide was formed. Procedures used for low dose levels in rats were applied to man, where 0.5 to 0.7 mg. per kg. yields in the urine less than 1% of the dose as unchanged BHA, and 27 to 77% as the glucuro-

These results are discussed in relation to differences in carbohydrate metabolism between young lambs and mature sheep. The authors acknowledge the help of Mr L. G. Veitch of the C.S.I.R.O. Division of Mathematical Statistics foi' the statistical analyses of the results, and of the late Mr N. F. Henschke of the Division of Biochemistry and General Nutrition for the preparation of the glucosotriazoles.

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