The article analyzes the problem of assesment of business risks of the Logistics chain from the point of storage to the end-user based on medicine retail case. The problem of the article – how to evaluate and manage the business risks of the logistics chain? The purpose of a research – after conducting a thorough scientific literature analysis, to define the business risks affecting the Logistics chain and to evaluate them according the impact on the Logistics chain, thus creating a basis for a more efficient management of these risks. The research was conducted using Analytical hierarchical process method in a medicine retail sector in Lithuania. It has been determined that the most important risk factor, affecting the Logistics chain from the point of storage to the end user, is the demand. Three of the following risk factors: operational risk, information dissemination risk and financial risk are almost equally important, with supply and environmental factors being of the least importance.