BACKGROUND: Cardiovascular diseases (CVDs) are a major cause of mortality around the world. At present, almost half of the non-communicable diseases are CVDs. According to the literature review, CVD disease and the associated risk factors are high among Saudi adults. It has not been studied to determine at which age the majority of adults acquire the risk factors. We hypothesized and planned to assess CVD risk factors among medical students. AIM: The main objective of this study is to determine the prevalence of CVD risk factors among male and female medical students in Qassim University. METHODS: A cross-sectional study surveyed 188 males and female medical students in Qassim University. They were selected by random sampling technique. The data were collected by using a questionnaire included (age, gender, height, weight, waist circumference, blood pressure, random blood glucose, smoking habits, physical activity, and stress scale). After the data collection, it was entered and analyzed by SPSS. RESULTS: About 9.6% of male students were smokers, while there is no history of smoking among female students. About 18.2% of males were found obese, while obesity was lower among females (4.2%). The random blood glucose for males and females was within normal limits, but the measured blood pressure showed a higher percentage of elevated blood pressure among males (47.8%) in comparison to females (25.4%). Perceived stress scale exhibited that females were getting a greater percentage of high stress (34.3%), while in males, it was 14.4%. CONCLUSION: Many risk factors were greater among males, including elevated blood pressure 47.8%, obesity 18.2%, and smoking 9.6%. On the other hand, these risk factors were lower in females, but they have a higher stress scale 34.3% in comparison to males.