In this study, we will study the biochemical characters of the resins for the different species of Commiphora genus through investigation of the in vitro anti-oxidant activity of the crude extracts of resins for five species of Commiphora. The free radical scavenging activity will be measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Also the total phenolic content was evaluated according to the Folin-Ciocalteu procedure. On the other hand the determination of the inhibitory effects of each of the extracts on the growth of selected bacterial and fungal was investigated on the pathogenic selected species. The results of this study are aiming to help in the development of biochemical analysis of resins which contributed to distinguish between plant species, to employ the plant extracts in the medical field and the possibility of their use in the treatment of many microbial diseases.