Recent attention has been given to the high frequency of coexisting anxiety and depressive symptoms that has served to challenge the more traditional view that these two disorders are typically discrete syndromes. Furthermore, research suggests that less severe states of anxiety and depression continue to be overlooked, despite their capacity to produce significant psychosocial impairment. Given the implications for diagnostic and treatment outcome, psychologists need to be aware of the epidemiology, clinical presentations, and treatment strategies surrounding comorbid and subthreshold anxiety and depression. We review the literature, present issues related to these syndromes, and discuss the implications for diagnostic and clinical activities. RAFAEL A. RIVAS-VAZQUEZ received his PsyD in clinical psychology from Nova Southeastern University and completed his predoctoral internship at Harvard Medical School/Massachusetts General Hospital. He received his postdoctoral MS in clinical psychopharmacology from Nova Southeastern University in 2001. He is currently adjunct faculty in psychology at University of Miami. His research interests include psychopharmacology, depression, Alzheimer's disease, and cross-cultural assessment and treatment issues. DALIA SAFFA-BILLER received her PsyD in clinical psychology from Nova Southeastern University in 1997 and completed her predoctoral internship at Citrus Health Network, Inc., Hialeah, FL. She is the director at the Weston Center for Psychological Services in Weston, FL. Her research interests include parenting and custody issues. IVONNE RUIZ received her PsyD in clinical psychology from Nova Southeastern University in 2000 and completed her predoctoral internship at Citrus Health Network, Inc. She is the clinical coordinator of the School and Community Based Clinical Services at Citrus Health Network. Her research interests include pervasive developmental disorder and childhood assessment and treatment. MARK A. BLAIS received his PsyD in clinical psychology from Nova Southeastern University in 1990. He is the associate chief of psychology at Massachusetts General Hospital and is associate professor at Harvard Medical School. His research interests include psychological assessment, psychotherapy outcome, and personality disorders. ANA RIVAS-VAZQUEZ received her PhD from the University of Miami in 1969 and her postdoctoral MS in clinical psychopharmacology from Nova Southeastern University in 2001. She was board certified in clinical psychology in 1988. She