Objective: This review is aimed to evaluate the effect of implementing the septic bundle on critically ill patients’ outcomes. Methodology: Cochrane Collaboration, MEDLINE, CINAHL, EMBASE, Science Direct, Web of Science, Scopus and PubMed were searched, covering the period 2008 to 2019. Only cohort, case-control and randomized controlled trial studies with full text in English were eligible. Studies that discussed the effect of implementing the septic bundle on critically ill patients' outcomes were only included. Results: Out of 1,551 articles searched, and after screening inclusion and exclusion criteria; ten articles only were met the inclusion criteria which have considered the effect of implementing a septic bundle on critically ill patients’ outcomes. All of these ten studies revealed a significant effect of the septic bundle on the clinical outcomes of critically ill patients especially mortality. Conclusion: This review confirmed that implementing septic bundle for critically ill patients has been significantly reduced outcomes which are length of hospital stay, length of stay at emergency department, mortality probability, admission to the intensive care unit and mechanical ventilation.