Wireless no-touch flexible ureteroscopy with the new flexible instruments is a feasible and safe technique for diagnostic and therapeutic procedures in most patients, irrespective of the location of the pathology, including the distal ureter. These ureteroscopes, with their exaggerated deflection, are ushering in a new era of endoscopic treatment of the upper urinary tract. Greater instrument deflectability and control can lead to shorter procedures and fewer treatment failures.