While introducing the novel structural method, this paper compares the behavior of composite panels comprised of cold-rolled galvanized sheets infilled with the foamed concrete and the fire-resistance polyurethane foam. A series of axial and bending tests are carried out on the composite panels with mentioned fillers; also, the function of the wire mesh and surrounding cold-rolled galvanized sheets with different thicknesses and different fillers are investigated in an attempt to know the effects of mentioned sheets on the final strength. The results show that applying the fire-resistance polyurethane foam performs better in enhancing the bending and the axial strength of composite panels in comparison with the foamed concrete filler. By this combined system with foamed concrete as infilling material, the cold-rolled galvanized sheets, which endure low bending and axial tension, have been able to withstand bending and axial load around 1.92–4.08 N/mm2 and 0.98–1.074 N/mm2, respectively. In addition to the aforementioned composite system, those panels with fire-resistance polyurethane foam as infilling material, apart from the greater lightness, around 40% lighter, have been able to withstand more with approximately 50% and 10% higher bending and axial load, respectively.