BACKGROUND Higher incidence of LBP is reported in Indian population in younger patients due to occupational exposure and lack of exercise. In general, LBP is managed with the short-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and centrally acting skeletal muscle relaxants. Aim-To compare the safety and efficacy of Thiocolchicoside and Chlorzoxazone in the treatment of low back pain associated with muscle spasm. MATERIALS AND METHODS This non-randomised controlled trial was conducted with 60 outpatients suffering from LBP who met inclusion and exclusion criteria. Finger-to-floor distance, Straight leg raising test, Pain assessment scale and Safety measures were used to measure the pain score on 1 st and 7 th day during treatment. The sample size estimation was also done at conveniences. RESULTS The baseline mean age for Group A and Group B was 48.9 ± 8.52 and 51.17 ± 8.15 respectively. On 1 st day, the mean pain score of Group A and Group B was 6.37 ± 1.63 and 6.43 ± 1.79 and on 7 th day the mean pain score was reduced to 2.17 ± 1.31 and 1.33 ± 1.63 respectively. There was statistically significant reduction in mean pain score in Group B compared to Group A at the end of the treatment. CONCLUSION Both the drug regimens were found to be effective, while Chlorzoxazone had higher efficacy compared to Thiocolchicoside at the end of treatment, but it was not statistically significant.