Nowadays, membrane bioreactor (MBR) is an advanced available technology for wastewater treatment due to technical innovations and cost reduction. Especially, the high biomass concentration and long sludge retention time are favourable for the biodegradation of organic pollutants and nitrification. This research aims to study on the treatment performance of two lab-scale submerged membrane bioreactors treating hospital wastewater. One was operated at low fluxes (2, 4, 6 LMH) and the other at higher fluxes (10, 15, 20 LMH). Polyester-urethane cube sponge media (20 % v/v) was added into both reactors for fouling control and simultaneous nitrification denitrification (SND). The results showed that organic removal efficiencies were improved with an increase in flux. The removal efficiencies of COD and total nitrogen were 85-89 % and 26-42 % at low fluxes and 96-97 %, 53-65 % at higher fluxes, respectively. The treated water quality complied with Vietnam National Technical Regulation on health care wastewater, class A.