Cerebral small vessel disease (CSVD) is a group of diseases that originate from changes in cerebral small vessels and that cause many conditions, such as cognitive impairment. However, there is no effective therapy for these diseases. Recent studies have suggested that inflammation is associated with this disease. Cyclooxygenase-2 (cox-2) is an inflammatory mediator; however, whether a cox-2 inhibitor could protect against the CSVD progression remains unknown. In the present study, stroke-prone spontaneously hypertensive rats (SHRsp) were used as a model of CSVD, and Sprague Dawley (SD) rats served as the control. SHRsp were treated with the cox-2 inhibitor celecoxib or vehicle. The Morris water maze test was performed, and vascular morphometry and the expression of collagen I and fibronectin were examined in cerebral small vessels and cerebral tissue. The results revealed that thickened small veesel walls, increased expression of collagen I and fibronectin and impaired cognitive function in SHRsp compared with SD rats. Additionally, celecoxib significantly down-regulated the expression of collagen I and fibronectin, attenuated the increase in vascular wall thickness and ameliorates the cognitive impairment. Our study indicated that this cox-2 inhibitor may serve as a promising candidate for the pharmacological intervention of CSVD.

Rationale: Mallet finger fracture is a common sports-related injury that may lead to the tearing of extensor tendon and protrusion of a bony fragment located at the base of the distal phalanx. We affirmed that the elastic fixation of with two K-wires technique is a good method to deal with Mallet Finger fractures that fractures could gain effective fixation than the conventional treatment method and avoid surgical incision complication Patient concerns: We reported a 33-year-old female patient came to our hospital complaining of mild pain, swelling and her right little finger was deformed because of sport's injury. Diagnosis: Acute mallet finger fracture type IV B according to Doyle classification of mallet injuries. Interventions: We performed an emergency operation for the elastic fixation of the mallet finger fractures with two K-wires. Outcomes: After the surgery, the patient showed functional recovery. No evidence of recurrence was noted 6 months after the operation, and the patient showed no symptoms of sports-related injuries. Lessons: We discuss the clinical diagnosis, treatment, and follow-up of the patient and suggest that elastic fixation with two K-wires is a good method to treat mallet finger fractures.

Background: Osteoarthritis (OA) and rheumatoid arthritis (RA) is the most common joint disease. The aim of my current academic work is to identify important genes associated with OA and RA, clarify their underlying mechanisms, and define differences between OA and RA.Methods: Gene expression profiles of GSE55235 were available from Gene Expression Omnibus database. Differentially expressed genes between 1) OA tissues and normal tissues, 2) RA tissues and normal tissues, were picked out by GEO2R tool, Venn diagram software, and Volcanic map. Next, we made use of the Database for Annotation, Visualization and Integrated Discovery to analyze Kyoto Encyclopedia of Gene and Genome pathway and gene ontology. The protein-protein interaction of these DEGs was visualized by Cytoscape with Search Tool for the Retrieval of Interacting Genes. Of entire PPI network analyzed by Molecular Complex Detection plug-in and obtain central nodes. Then the central nodes were re-analysis via DAVID. We next obtained the intersection of the analysis results of GSE55457 and GSE55235 to verify the results. Finally, potential biomarkers were evaluated by receiver operating characteristic.Results: Twelve genes were found to be significantly enriched in the TNF signaling pathway in OA, and eleven genes were found to be significantly enriched in the Chemokine signaling pathway in RA. Receiver operating characteristic curve suggested that the detection of JUN in OA and CCL5, CXCL9, CXCL10, CXCL11, CXCL13 in RA exhibited a high diagnostic performance.Conclusions: We have identified six significantly DEGs on the basis of integrated bioinformatical methods, which could be potential targets for differential diagnosis for OA and RA.