COVID-19 has presented itself with an extreme impact on the resources of its epi-centres. In Uganda, there is uncertainty about what will happen especially in the main urban hub, the Greater Kampala Metropolitan Area (GKMA). Consequently, public health professionals have scrambled into resource-driven strategies and planning to tame the spread. This paper, therefore, deploys spatial modelling to contribute to an understanding of the spatial variation of COVID-19 vulnerability in the GKMA using the socioeconomic characteristics of the region. Based on expert opinion on the prevailing novel Coronavirus, spatially driven indicators were generated to assess vulnerability. Through an online survey and auxiliary datasets, these indicators were transformed, classified, and weighted based on the BBC vulnerability framework. These were spatially modelled to assess the vulnerability indices. The resultant continuous indices were aggregated, explicitly zoned, classified, and ranked based on parishes. The resultant spatial nature of vulnerability to COVID-19 in the GKMA sprawls out of major urban areas, diffuses into the peri-urban, and thins into the sparsely populated areas. The high levels of vulnerability (24.5% parishes) are concentrated in the major towns where there are many shopping malls, transactional offices, and transport hubs. Nearly half the total parishes in the GKMA (47.3%) were moderately vulnerable, these constituted mainly the parishes on the outskirts of the major towns while 28.2% had a low vulnerability.