No abstract

Purpose. The aims were to correlate individual marrow metabolic changes after chemotherapy with bone marrow biopsy (BMBx) for its potential value of personalized care in lymphoma. Methods. 26 patients (mean age, 58 ± 15 y; 13 female, 13 male) with follicular lymphoma or diffuse large B-cell lymphoma, referred to FDG-PET/CT imaging, who had BMBx from unilateral or bilateral iliac crest(s) before chemotherapy, were studied retrospectively. The maximal standardized uptake value (SUV) was measured from BMBx site over the same area on both initial staging and first available restaging FDG-PET/CT scan. Results. 35 BMBx sites in 26 patients were evaluated. 12 of 35 sites were BMBx positive with interval decrease in SUV in 11 of 12 sites (92%). The remaining 23 of 35 sites were BMBx negative with interval increase in SUV in 21 of 23 sites (91%). The correlation between SUV change over the BMBx site before and after chemotherapy and BMBx result was significant (P < 0.0001). Conclusions. This preliminary result demonstrates a strong correlation between marrow metabolic changes (as determined by FDG PET) after chemotherapy and bone marrow involvement proven by biopsy. This may provide a retrospective means of personalized management of marrow involvement in deciding whether to deliver more extended therapy or closer followup of lymphoma patients.

This essay provides a dimensional analysis of the various manners in which mathematics, phenomenology, and theology claim to make present or mediate infinity. Edmund Husserl's 1935 lecture, Philosophy and the Crisis of European Humanity, because engaged with each discipline to various degrees, will function as our primary, preparatory text. Husserl's discussion of the ideal objects of mathematics and the Greek attitude will call for further analysis of the relation between mathematics and infinity. Similarly, intentional infinities, insofar as related to transcendental phenomenology, will be compared to Jean-Luc Marion's distinct phenomenology of the icon. Next, the ways in which the infinite God is conceptualised by Husserl and Marion will be juxtaposed in order to demonstrate their disparate, theological thinking. Finally, the notion of multiple infinities will be analogically extended from set theory to the discursive wholes of mathematics, phenomenology, and theology in order to suggest a novel understanding of the role of the infinite within postmodern fundamental theology.

On brain perfusion SPECT, a primary brain lesion presents as a localized defect that corresponds to the mass lesion. (99m)Tc-HMPAO images generally show a focal defect in the region of abnormality, whether containing necrotic tissue, recurrent tumor, or both. Further characterization with MR imaging is needed to confirm the diagnosis, as demonstrated in this case report.