The Regency that rich in the natural resources needs many stake holders to attract the investors to open new enterprises or collaborate the Micro, Small and Medium Enterprises (SMEs). A map out procedure was carried ou to seek the natural resources as backbone of community development and business growth in Simalungun Regency of North Sumatra Province of Indonesia. Data collection was made by seeking the data of official documents and studies reports. Data obtained revealed that Simalungun Regency in 2019 and 2020 has a great economic growth in agriculture. It found that the sector of forestry, agriculture and fisheries in 2019 increases 6.15 % and in 2020 it grew 9 % . Beside it has registered 1,200 SMEs, it will make the increase of SMEs whenever the Agropolitan Development Plan set up within 5 years. Simalungun Regency has very huge natural resources that needed to be developed as an agropolitan area to support the Micro, Small and Medium Enterprises (SMEs).