Apparent molal volumes of two local anesthetics, lidocaine HCl and procaine HCl, in water at (298.15, 303.15, and 310.15) K have been measured in the concentration range from (0.01 to 0.1) mol‚kg -1 . The densities were obtained with a magnetic float densimeter. The concentration dependence of V φ has been calculated using the Redlich and Meyer equation. The values of apparent molal volumes at infinite dilution, V φ 0 , the empirical constants B V , and the partial molal expansibilities, E φ 0 , were calculated. The results are interpreted in terms of competitive effects between electrostriction and hydrophobic solvation.

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