In 1994, a study of nickel release and allergic contact dermatitis from nickel-plated metals and stainless steels was published in this journal. It was shown that low-sulfur stainless steel grades like AISI 304, 316L or 430 (S < or = 0.007%) release less than 0.03 microgram/cm2/week of nickel in acid artificial sweat and elicit no reactions in patients already sensitized to nickel. In contrast, nickel-plated samples release around 100 micrograms/cm2/week of Ni and high-sulfur stainless steel (AISI 303-S approximately 0.3%) releases about 1.5 micrograms/cm2/week in this acid artificial sweat. Applied on patients sensitized to nickel, these metals elicit positive reactions in 96% and 14%, respectively, of the patients. The main conclusion was that low-sulfur stainless steels like AISI 304, 316L or 430, even when containing Ni, should not elicit nickel contact dermatitis, while metals having a mean corrosion resistance like a high-sulfur stainless steel (AISI 303) or nickel-plated steel should be avoided. The determining characteristic was in fact the corrosion resistance in chloride media, which, for stainless steels, is connected, among other factors, to the sulfur content. Thus, a question remained concerning the grades with an intermediate sulfur content, around 0.03%, which were not studied. They are the object of the study presented in this paper. 3 tests were performed: leaching experiments, dimethylglyoxime and HNO3 spot tests, and clinical patch tests; however, only stainless steels were tested: a low-sulfur AISI 304 and AISI 303 as references and 3 grades with a sulfur content around 0.03%: AISI 304L, AISI 304L added with Ca, AISI 304L+Cu. Leaching experiments showed that the 4 non-resulfurised grades released less than 0.5 microgram/cm2/week in acid sweat while the reulfurized AISI 303 released around or more than 0.5 microgram/cm2/week. This is explained by the poorer corrosion resistance of the resulfurized grade. Yet all these grades had the same reaction to the DMG test (negative result), which shows again its lack of sensitivity. In contrast, the HNO3 spot test distinguished AISI 303 from the non-resulfurized grades. Clinical patch tests again showed that some patients (4%) were intolerant to AISI 303, while none were intolerant to the other grades. Thus, this study confirms that non-resulfurized stainless steels (S < or = 0.03%) like Ni-containing 304 and 304L should not elicit Ni contact dermatitis, while the resulfurized grades (S > 0.1%) should be avoided.

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Records of grape harvest dates (GHDs) are the oldest and the longest continuous phenological data in Europe. However, many available series, including the wellknown (Dijon) Burgundy series, are error prone because scholars so far have uncritically drawn the data from 19th century publications instead of going back to the archives. The GHDs from the famous vine region of Beaune (Burgundy) were entirely drawn from the archives and critically cross-checked with narrative evidence. In order to reconstruct temperature, the series was calibrated against the long Paris temperature series comprising the 360 years from 1659 to 2018. The 664-year-long Beaune series from 1354 to 2018 is also significantly correlated with tree-ring and documentary proxy evidence as well as with the central European temperature series (from 1500). The series is clearly subdivided into two parts. From 1354 to 1987 grapes were on average picked from 28 September on, whereby during the last 31-year-long period of rapid warming from 1988 to 2018 harvests began 13 d earlier. Early harvest dates are shown to be accompanied by high pressure over western-central Europe and atmospheric blocking over Denmark. The 33 extremely early harvests comprising the fifth percentile bracket of GHDs are unevenly distributed over time; 21 of them occurred between 1393 and 1719, while this is the case for just 5 years between 1720 and 2002. Since the hot summer of 2003, 8 out of 16 spring-summer periods were outstanding according to the statistics of the last 664 years, no less than 5 among them within the last 8 years. In the Paris temperature measurements since 1659, April-to-July temperature reached the highest value ever in 2018. In sum, the 664-year-long Beaune GHD series demonstrates that outstanding hot and dry years in the past were outliers, while they have become the norm since the transition to rapid warming in 1988.