Sex estimation remains one of the most important steps in a forensic anthropology context, especially when dealing with deteriorated or fragmented skeletal remains. In this respect, the need for the permanent actualisation of study database, as well of the skeletal remains is obvious. Therefore, besides classical skeletal collections an important amount of data can be obtained from computed imaging of the skeletal system, namely CT scans. The CT scans have the advantage of being virtually unlimited in number, not having any interference with secular trends, individuals being of known age and sex as well as increase in accessibility and applicability of data, for subsequent statistical and complex analysis (for instance, geometric morphometric). In the following review, we have gathered and compared some of the most significant studies in the field of physical and forensic anthropology focusing on sexual dimorphism on the skull, both on skeletal collections and CT scans. The results of the studies were similar in terms of sexing accuracy, thus allowing us to conclude that using CT scans in forensic anthropology is a viable and sometimes better option than skeletal collections, in term of data acquisition.