Phytochemicals present in detox juices and probiotics have demonstrated protective effects on cardiovascular risk factors. The consumption of these products alone modulate metabolic mechanisms and biomarkers. However, the effects of the combination of detox juice and probioticshave not yet been evaluated on atherogenic parameters. A randomized controlled study was carried out with 40 healthy volunteers (20 men and 20 women), aged between 18 and 50 years old. The volunteers ingested 200mL of juice for 30 days. Before and after supplementation, the anthropometric and lipid profiles and plasma concentrations of TBARS, Myeloperoxidase, Glutathione, Protein and non-protein Thiols and Vitamin C were analyzed. A reduction in LDL-c (p=0.05), triglycerides (p=0.05) and a significant increase in HDL-c (p=0.002) was observed. There was a significant decrease in the concentrations of TBARS (p=0.01), myeloperoxidases (p= 0.02) and a significant increase in the Vitamin C and GSH (p= 0.01). There wasn`t improvement in anthropometric parameters and total cholesterol. The findings highlight that supplementation with probiotic detox juice improves the lipid and antioxidant profile, suggesting a possible positive effect in reducing the risk of cardiovascular disease in healthy volunteers. Nevertheless, more robust researches with a prolonged treatment period should be conducted.
Introduction: Farmers use agricultural pesticides for crop maintenance and pest control. The exposure to these compounds generates a multitude of harmful effects to human health, causing biochemical changes. Objective: The aim of this study was to evaluate possible changes in pesticide intoxication markers, liver, kidney and behavioral profiles resulting from exposure to agricultural pesticides in rural workers. Methods: A crosssectional study was conducted with 34 farmers (8 women and 26 men). A quality of life questionnaire was applied and blood samples were collected for analysis of liver (ALT, AST, GGT, ALP), kidney (Urea, Creatinine) and intoxication (Cholinesterase) profile biomarkers. Data were analyzed using an analysis of variance (ANOVA). Results: The renal and intoxication profile values showed no significant differences between the groups by ANOVA statistical test, however, one liver profile value (ALT) showed significant difference between the groups. It was also observed that in all groups there were values of all profiles outside the reference limits. Conclusion: The results of the study show abnormalities in the liver profile of the "Good" group, by the change in ALT reference values, possibly due to the non-use of PPE, however, there were metabolic changes in all groups, including the marker of intoxication from pesticides, which leads
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