<p>Objetivo: identificar a atuação do enfermeiro da Estratégia Saúde da Família na detecção precoce do Transtorno do Espectro Autista em crianças. Método: pesquisa descritiva, exploratória, qualitativa realizada numa capital do Nordeste, Brasil. Participaram 10 enfermeiros efetivos, concursados e em exercício na Estratégia Saúde da Família. A coleta de dados ocorreu em 2014 por meio de entrevista individual, observação direta e diário de campo. Material tratado pela análise temática, interpretado pelo referencial das Diretrizes de Atenção à Reabilitação da Pessoa com Transtorno do Espectro Autista. Resultados: foram áreas temáticas: percepção, estratégias e intervenções do enfermeiro sobre sinais e sintomas; dificuldades relatadas à detecção precoce; construção do conhecimento sobre a temática; e sentimentos dos profissionais ao acompanharem crianças com Transtorno do Espectro Autista. Conclusão: enfermeiros da Estratégia Saúde da Família apresentaram deficiências na detecção precoce do Transtorno do Espectro Autista em crianças. <br />Descritores: Transtorno autístico. Cuidado da criança. Estratégia Saúde da Família. Intervenção precoce (Educação).</p>

The aim of the present study was to investigate the possibility of different effects of the hydrophobic statin simvastatin and the hydrophilic statin pravastatin on the remodelling process in the overloaded left ventricle and renal cortex of SHRs (spontaneously hypertensive rats). Fifteen SHRs were treated for 40 days with simvastatin, pravastatin or placebo (water) via orogastric administration. Left ventricle and renal cortex were examined by light microscopy and stereology. LV (left ventricular) cardiomyocyte nuclei (N[cmn]) and glomeruli (N[gl]) numbers were estimated by the dissector method. BP (blood pressure) and serum triacylglycerols (triglycerides) were lower in the statin-treated groups than in the untreated control group. The volume density of the interstitial connective tissue was smaller and length density of the intramyocardial arteries, as well as the arteries/cardiomyocyte ratio, was greater in the statin-treated groups than in the control group. No difference was observed between the two statin-treated groups. The cross-sectional cardiomyocyte area was significantly smaller in the simvastatin-treated group than in the control or pravastatin-treated groups, and it was smaller in the pravastatin-treated group than in the control group. N[cmn] and N[gl] were greater in the two statin-treated groups than in the control group, but no significant difference was observed between the two statin-treated groups. In conclusion, administration of the statins simvastatin and pravastatin to SHRs effectively prevented the elevation in BP and serum triaclyglycerols, and also attenuated adverse cardiac and kidney remodelling by preventing LV hypertrophy, enhancing myocardial vascularization with the decrease in interstitial fibrosis and attenuating cardiomyocyte and glomerular loss.

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The aim of the present study was to analyze if the genetic polymorphisms might predict suicide attempts in mental disorder patients. The literature review and meta-analysis were conducted using the PubMed/Medline, Web of science and Scopus database using the terms: "5-HTT or SLC6A4 or 5-SERT and suicide, suicidal ideation or suicidal behavior or suicidal attempt". Thirty articles were analyzed. We found 17 articles that showed association and 13 articles that showed no association between LPR serotonin transporter polymorphism and suicide. A higher study of suicide identified the serotonin transporter polymorphism in patients with schizophrenia, mental disorder, major depression and bipolar disorder. There is an association between the serotonin-transporter-linked polymorphic region and suicidal behavior. The mental disorders with greater relationship with the suicide were the bipolar disorder, major depression and schizophrenia. The L allele had higher risk for suicide.

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