Cancer is the transformation of healthy cells into tumor cells in a multistage process that can affect any organ of the body. This disease is the second leading cause of death globally. There are now more than 10 million cancer cases per year worldwide, and the most common occurs in the lung, breast, and colon. Several studies demonstrate that lifestyle and eating habits are directly related to tumor cells’ appearance, such as high body mass index, low fruit and vegetable intake, lack of physical activity, and tobacco and alcohol use. It is widely believed that diet and nutrients can act as cancer risk-modifiers throughout the process of carcinogenesis, including initiation, promotion, progression, and/or conversion. Different plants have been the source of therapeutic agents. Plant-derived compounds have become indispensable for modern pharmacotherapy, and phenolic compounds are one of the most investigated due to their antitumor activity. Their cellular targets and mechanisms are compiled in the present work. Phenolic compounds are secondary metabolites present in large quantities in medicinal herbs and dietary plants (e.g., fruits, vegetables, and spices). They possess a diverse range of beneficial biological activities, which contribute to their potent effects on inhibiting carcinogenesis. Some benefits include cell proliferation and angiogenesis inhibition and anti-inflammatory, antioxidant, and antimetastatic activities. Thus, the present review supports the recommendations for consuming foods and drinks rich in phenolic compounds to prevent and possibly treat cancer.
Prezados congressistas e demais leitores, estes são os Anais do II Congresso Nacional de Educação Contra o Tabagismo - CONECT, celebrado entre os dias 21 e 23 de outubro de 2022 de forma virtual. É com grande satisfação que a Comissão Científica do II CONECT, em parceria com a renomada Editora Pasteur, organizaram os Anais contendo os resumos aprovados no congresso, com o escopo de alertar os ouvintes e leitores quanto aos inúmeros riscos do tabagismo, que é um importante fator de risco para a perda da qualidade de vida e também para o desenvolvimento de várias doenças, sendo um hábito evitável que traz inúmeros impactos negativos tanto a nível individual, quanto social. Foram aprovados e publicados 18 trabalhos, os quais abrangeram diferentes áreas temáticas relacionadas às repercussões negativas do hábito de fumar, demonstrando, dessa maneira, a magnitude dos prejuízos biopsicossociais atreladas a esse vício. À guisa de democratizar o debate e embasar cientificamente tal discussão, os Anais, bem como toda a programação científica do II CONECT, foram cuidadosamente organizados, com o intuito de unificar o engajamento dos profissionais de saúde contra o perene hábito de fumar, que - após a introdução dos dispositivos eletrônicos, progressivamente, tem se tornado mais comum, principalmente entre a população mais jovem. Estes Anais refletem o comprometimento dos estudantes, dos docentes e dos pesquisadores com a prática de prevenção em saúde e com a promoção da qualidade de vida. O CONECT, ainda em sua tenra formação, sustenta o valor do cuidado preventivo, acreditando que a principal fonte de disseminação dos bons hábitos, são os profissionais de saúde.
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