Polymethoxylated flavones (PMFs) have been associated with increased antioxidant activity in animal models. The effects of tangeretin (TAN) and nobiletin (NOB) on antioxidant activity in the blood and liver of rats were evaluated. Groups of rats were treated with 200 mg/kg bw/day of TAN or NOB, or placebo, for 15 days. Parental compounds and their metabolites were assessed in the liver by chromatographic analysis, in addition to α-tocopherol and retinol in the blood serum. Both TAN and NOB supplements were able to reduce malonaldehyde (MDA) in the rat’s blood by 22% and 18%, respectively, but only NOB increased redox reaction by 3%. Blood levels of retinol and α-tocopherol increased under TAN by 59% and 20%, respectively, but were not affected by NOB. Eight NOB metabolites were detected in the liver, but only two TAN metabolites were identified in low concentration. In conclusion, NOB improved antioxidant capacity and reduced lipid peroxidation, while increased levels of retinol and α-tocopherol after TAN supplement may have contributed to decreased blood lipid peroxidation.
ResumoDentre as espécies frutíferas do Cerrado brasileiro, o pequi é muito popular nas regiões onde é extraído. Comumente utilizado em pratos típicos, na indústria medicinal, cosmética e na artesanal, também se estuda o seu potencial na produção de combustível. Assim, este artigo procurou ponderar sobre a divulgação deste fruto na imprensa, por meio do sistema de busca do site da Folha de S.Paulo e aplicando a análise de conteúdo, proposta por Bardin, além da pesquisa documental e bibliográfica. A justificativa para esta pesquisa é a de que o pequi é um fruto de grande importância na economia sustentável e, mesmo assim, pouco se fala sobre ele na grande mídia. Resulta daí que, pelo analisado, pouco se fala sobre o pequi na mídia e seu foco é, principalmente, o jornalismo cultural, na culinária.
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