A complex clinical case was observed of a 6 years old boy, which does not seem to fit into any of the known clinical pictures. The main features of the syndrome could possibly be explained by the hyperfunction of a single hormone, viz. the growth hormone in its multiple functions. CASE REPORT M. C., the 6 years old, white, blue-eyed patient, of Italian extraction, lives in the State of Rio, and was first seen in January 1952, later on in June of the same year.

Palladium-catalyzed carbonylation reaction has surfaced as a robust tool for insertion of the carbonyl group into organic molecules, and in the last decades enormous progress has been made. Nowadays, a plethora of methodologies is available to synthesize all kinds of carbonyl compounds. However, the focus has shifted during recent years to address rising concerns related to developing safe, cost-efficient, and more sustainable methodologies. The use of different carbon monoxide (CO) precursors/sources, avoiding handling of highly toxic and flammable gaseous carbon monoxide, and substituting nonrenewable solvents for those derived from renewable feedstock have contributed to aim these goals. In this review, we will discuss the advent of the application of renewable solvents to improve the sustainability and environmentally benign nature of Pd-catalyzed carbonylation reactions.

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