Vitamin B12 (VB12) is an essential water-soluble vitamin that also known as Cobalamin. The various forms of cobalamin include cyanocobalamin, hydroxycobalamin, methyl cobalamin and 5-deoxyadenosylcobalamin.It has vital functions of human body include; DNA synthesis, folate metabolism, optimal haemopoiesis, neurological function. Dietary deficiency of VB12 is rare, except in elderly people and long-term vegans. Nutritional deficiency, malabsorption syndromes, and gastrointestinal disorder are the most common causes of VB12 deficiency. Recently, studies documented that there is a deficiency of VB12 and folic acid in obese people compared with normal BMI controls. This review was aimed to evaluate VB12 level among patients with morbid obesity. The current data concluded that there is negative correlation between VB12 and body mass index. For that reason, VB12 must be routinely tested in morbidly obese people.
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