Recent studies in various countries have shown controversy regarding students' willingness to care for human immunodeficiency virus (HIV)-infected patients as well as factors associated with students' decisions about this issue. This survey, based on the Theory of Planned Behavior, explored factors associated with Israeli nursing students' willingness to care for HIV-infected patients in the future. The results suggest that appropriate education and experience in caring for HIV-infected patients are critical for improving students' willingness to care for these patients.