Neonatal illjection (day 5) of male CF1 mice with 50 pg of estradiol undecylate resulted in decreased body and testes weight and adrenal hypertrophy when these animals were examined at 95 days of age. The adrenal hypertrophy was associated with a n increase in adrenal total cholesterol and plasma corticosterone after maximal ACTH stimulation. Orchiectomy of estradiol-injected or oil-iqiected control males did not significantly modify their response to ACTH stimulation. It is concluded that neonatal estrogenization of male mice causes, in addition to previously reported defects in subsequent reproductive function, long-lasting changes in adrenal function.

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