Sobre estas páginas, el lector se hará eco de las complejas similitudes que existieron entre las epidemias del pasado, particularmente del medievo, y la vigente pandemia mundial; así como de las actuaciones preventivas que las urbes castellanas llevaron a cabo para contenerlas. Este artículo se aproxima a ofrecer una visión completa del fenómeno histórico de la Peste Negra, analizando la cronología epidémica de la enfermedad en la corona de Castilla, en sus diferentes ámbitos de desarrollo, durante los siglos bajomedievales. El alcance actual de la investigación, limitado a la segunda mitad del siglo XIV, se complementa con la evidencia de nuevos brotes pestilentes testimoniados en la última centuria medieval, un estudio novedoso favorecido por los procesos de digitalización documental
Mutations at chromosome 19 are rare, and reports in the literature are scarce and clinically variable. This chromosome has a high genetic density, and hence a given deletion can cause distinctive effects on body systems and, in addition, result in a characteristic phenotype.
We report the case of a patient who presented with distinctive signs and symptoms such as delayed psychomotor development, severe postnatal delay, dolichocephaly, polyotia, and ocular hypertelorism. Even though all cases with a chromosome 19 deletion do not present in the same way, they still share some clinical manifestations that should be considered, which prompted us to present a summary of the available literature on the subject. Additionally, to our knowledge, this is the first and only case with polyotia in its phenotype to be reported in Colombia to date.
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