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The excitement conveyed by the 1968 Annual Reports continues to shine through many of the articles in the 1969 volume. After reading other recent periodic review volumes, one cannot escape the feeling that the editors of this series must have impressed upon their contributors their own enthusiasm about the future of medicinal chemistry, technical, scientific, and regulatory difficulties notwithstanding. Indeed, one feels that the lack of adequate understanding of the etiology of many diseases, and of pertinent test methods, and of means of discovering new leads, is taken up as a challenge rather than as a lamentable situation. Somehow the future of medicinal chemistry seems brighter from these Reports, than predicted by many recent symposia which appear to have emphasized bottlenecks rather than glimpses of an experimentally defendable future.